FibroDerm is Cytoprosthetic Hybrid that is composed of skin fibroblasts cultured on a thin membrane, a special scaffold, composed of an esterified form of hyaluronic acid. Fibroblasts are the main components of the dermis. They are essential for the regeneration of the dermal skin layer and therefore the treatment of wounds, ulcers and burns, as they produce collagen and other extracellular matrix proteins.
The 3-D culture of skin fibroblasts on a hyaluronic acid scaffold activates their growth, so that they form a new artificial dermis. When applied at the site of the injury, this new artificial dermis will be incorporated to the skin, promoting this way the closure of the wound, through the formation of a new dermal layer and the spontaneous re-epithelization of the skin.
In order to prepare FibroDerm, 2-3 small punch biopsies (3mm each) are collected from behind the ear of the patient (or even from some other part of the body). These punch biopsies are subsequently placed into a special tube containing a buffered medium and the samples are transferred to our laboratories. Upon arrival to our premises, skin samples are processed for the isolation of fibroblasts. The cells are tested for their quality and possible infections and then expanded in special incubators and culture media.
After approximately 4 weeks, when the appropriate number of cells is reached, the cells are cultured on a 3-D membrane (scaffold) for an additional 8 days for the formation of the FibroDerm. The Cytoprosthetic Hybrid is then sent to the hospital for its application on the wound, burn or ulcer.
Direct application of the FibroDerm on the wound, leads to:
- Full regeneration of skin layers
- Migration of additional keratinocytes & fibroblasts
- Re-epithelization of the skin